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  1. #21
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    I am going to try and get it from Canada. It appears to be the most affordable option for the brand.

  2. #22
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    Quote Originally Posted by mopes View Post
    Is it possible to increase dopamine levels in a nonaddictive, long term manner? If so, where would you start?
    for males adequate levels of testosterone is the best dopamine enhancer, and natural....

  3. #23
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    Quote Originally Posted by puerco911 View Post
    for males adequate levels of testosterone is the best dopamine enhancer, and natural....
    I would not be so sure about that... it is a "chicken & egg" thing. And personally, I believe that higher dopamine rather triggers more test production than vice versa
    visit my nutrition & exercise science blog!
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  4. #24
    Senior Member kassem23's Avatar
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    Quote Originally Posted by physicus007 View Post
    I would not be so sure about that... it is a "chicken & egg" thing. And personally, I believe that higher dopamine rather triggers more test production than vice versa
    Seriously? Do you have a reference for that?

  5. #25
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    Quote Originally Posted by puerco911 View Post
    for males adequate levels of testosterone is the best dopamine enhancer, and natural....
    Would love to get the test up a bit higher (540 total t @ 31 years old) but not sure there's much more I can do there. Appreciate the suggestion though.

  6. #26
    Senior Member kassem23's Avatar
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    Quote Originally Posted by mopes View Post
    Would love to get the test up a bit higher (540 total t @ 31 years old) but not sure there's much more I can do there. Appreciate the suggestion though.
    Clomiphene.

  7. #27
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    Quote Originally Posted by kassem23 View Post
    Clomiphene.
    Yeah I've been reading up on it, waiting to see what my lh/fsh levels come back at...

  8. #28
    Senior Member FunkOdyssey's Avatar
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    Quote Originally Posted by kassem23 View Post
    Seriously? Do you have a reference for that?
    I've read somewhere that Dr. Shippen uses selegiline to increase testosterone levels in cases of mild hypogonadism and mine were higher than usual while on it.
    "Also, can I rig some sort of enema out of household items?" -Tussman

    "I don't have the stamina for a 3-some, and I am a one-pump chump" -Ubiyca

  9. #29
    Senior Member Tussmann's Avatar
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    Males higher on social hierarchies, in other words those with constantly streaming DA in the reward pathway, are known to have much higher testosterone levels

  10. #30
    Senior Member Sanction's Avatar
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    Non-stimulant approach: have a rewarding adolescence.

    Adolescent social defeat alters markers of adult dopaminergic function.

    Stressful experiences during adolescence can alter the trajectory of neural development and contribute to psychiatric disorders in adulthood. We previously demonstrated that adolescent male rats exposed to repeated social defeat stress show changes in mesocorticolimbic dopamine content both at baseline and in response to amphetamine when tested in adulthood. In the present study we examined whether markers of adult dopamine function are also compromised by adolescent experience of social defeat. Given that the dopamine transporter as well as dopamine D1 receptors act as regulators of psychostimulant action, are stress sensitive and undergo changes during adolescence, quantitative autoradiography was used to measure [(3)H]-GBR12935 binding to the dopamine transporter and [(3)H]-SCH23390 binding to dopamine D1 receptors, respectively. Our results indicate that social defeat during adolescence led to higher dopamine transporter binding in the infralimbic region of the medial prefrontal cortex and higher dopamine D1 receptor binding in the caudate putamen, while other brain regions analyzed were comparable to controls. Thus it appears that social defeat during adolescence causes specific changes to the adult dopamine system, which may contribute to behavioral alterations and increased drug seeking.
    http://www.ncbi.nlm.nih.gov/pubmed/21741457

  11. Thanks NeuralFrequency, essential thanked for this post
  12. #31
    Senior Member adreno's Avatar
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    Quote Originally Posted by Sanction View Post
    Non-stimulant approach: have a rewarding adolescence.



    http://www.ncbi.nlm.nih.gov/pubmed/21741457
    In that case, I think I'll go back and change mine.

  13. #32
    Senior Member kassem23's Avatar
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    Quote Originally Posted by adreno View Post
    In that case, I think I'll go back and change mine.
    Your adolescence wasn't rewarding?

  14. #33
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    Quote Originally Posted by adreno View Post
    In that case, I think I'll go back and change mine.
    LOL. No kidding. Reading that just depresses me. Stuff that happened so many years ago and was completely out of my control has likely screwed up my neurobiology permanently. Fantastic.

  15. #34
    Senior Member adreno's Avatar
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    Quote Originally Posted by kassem23 View Post
    Your adolescence wasn't rewarding?
    Only in a chemical sense.

  16. #35
    Senior Member FunkOdyssey's Avatar
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    Quote Originally Posted by bdog527 View Post
    LOL. No kidding. Reading that just depresses me. Stuff that happened so many years ago and was completely out of my control has likely screwed up my neurobiology permanently. Fantastic.
    There has to be some way to reverse these changes though. I'm sure it's much more difficult than establishing them in adolescence but I think neuroplasticity must offer some hope. Maybe if you experience a few thousand rewarding social interactions in a row, something along those lines.
    "Also, can I rig some sort of enema out of household items?" -Tussman

    "I don't have the stamina for a 3-some, and I am a one-pump chump" -Ubiyca

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  18. #36
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    Quote Originally Posted by Sanction View Post
    Non-stimulant approach: have a rewarding adolescence.



    http://www.ncbi.nlm.nih.gov/pubmed/21741457
    Yeah, Sanction, stop posting stuff like that, it just depresses me more..

  19. #37
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    Quote Originally Posted by FunkOdyssey View Post
    There has to be some way to reverse these changes though. I'm sure it's much more difficult than establishing them in adolescence but I think neuroplasticity must offer some hope. Maybe if you experience a few thousand rewarding social interactions in a row, something along those lines.
    You think so? I just don't know. I mean that's my hope ultimately, but it seems that even with a marriage, a family of my own and all the rewarding experiences that come with it, my screwed up dysfunctional childhood and adolescence always haunt me. Of course, now I'm just whining, but I really do wonder if stuff like that is permanent, and then that leads to cycle of dysfunction that lasts over generations?

    I know that for me personally, my number 1 goal in life is that my children always have a loving, functional home that they feel safe in and can be happy. There is nothing more important for me than that.

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  21. #38
    Senior Member Sanction's Avatar
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    I quoted one study that had a very limited scope.
    Don't underestimate the effects of neuroplasticity/learning, self-insight and a good social environment in adulthood.

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  23. #39
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    Quote Originally Posted by FunkOdyssey View Post
    I've read somewhere that Dr. Shippen uses selegiline to increase testosterone levels in cases of mild hypogonadism and mine were higher than usual while on it.
    I've been interested in selegiline and that would be an added bonus. Have you experienced any tolerance or withdrawal to selegiline in your personal use? Not sure if I should stay away from it given my reaction to Ropinirole

  24. #40
    Senior Member FunkOdyssey's Avatar
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    Yes, I experienced all of the above: tolerance to the benefits, gradual development of negative side effects, and negative withdrawal effects. I don't think that is too uncommon either, or everyone would still be taking it. It's one of those things like piracetam, where 100 people try it, and when you poll them 1-2 years later, only a couple continued to use it.

    But since you could be part of that 1-2%, I don't know how much value my anecdote is for you (or anyone else).
    Last edited by FunkOdyssey; January 26th, 2012 at 04:34 AM.
    "Also, can I rig some sort of enema out of household items?" -Tussman

    "I don't have the stamina for a 3-some, and I am a one-pump chump" -Ubiyca

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