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  1. #1
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    Now what is this shit? Anyone care to elaborate?



    Coffee, CYP1A2 Genotype, and Risk of Myocardial Infarction



    Marilyn C. Cornelis, BSc; Ahmed El-Sohemy, PhD; Edmond K. Kabagambe, PhD; Hannia Campos, PhD



    JAMA. 2006;295:1135-1141.



    Context The association between coffee intake and risk of myocardial infarction (MI) remains controversial. Coffee is a major source of caffeine, which is metabolized by the polymorphic cytochrome P450 1A2 (CYP1A2) enzyme. Individuals who are homozygous for the CYP1A2*1A allele are "rapid" caffeine metabolizers, whereas carriers of the variant CYP1A2*1F are "slow" caffeine metabolizers.



    Objective To determine whether CYP1A2 genotype modifies the association between coffee consumption and risk of acute nonfatal MI.



    Design, Setting, and Participants Cases (n = 2014) with a first acute nonfatal MI and population-based controls (n = 2014) living in Costa Rica between 1994 and 2004, matched for age, sex, and area of residence, were genotyped by restriction fragment–length polymorphism polymerase chain reaction. A food frequency questionnaire was used to assess the intake of caffeinated coffee.



    Main Outcome Measure Relative risk of nonfatal MI associated with coffee intake, calculated using unconditional logistic regression.



    Results Fifty-five percent of cases (n = 1114) and 54% of controls (n = 1082) were carriers of the slow *1F allele. For carriers of the slow *1F allele, the multivariate-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) of nonfatal MI associated with consuming less than 1, 1, 2 to 3, and 4 or more cups of coffee per day were 1.00 (reference), 0.99 (0.69-1.44), 1.36 (1.01-1.83), and 1.64 (1.14-2.34), respectively. Corresponding ORs (95% CIs) for individuals with the rapid *1A/*1A genotype were 1.00, 0.75 (0.51-1.12), 0.78 (0.56-1.09), and 0.99 (0.66-1.48) (P = .04 for gene x coffee interaction). For individuals younger than the median age of 59 years, the ORs (95% CIs) associated with consuming less than 1, 1, 2 to 3, or 4 or more cups of coffee per day were 1.00, 1.24 (0.71-2.18), 1.67 (1.08-2.60), and 2.33 (1.39-3.89), respectively, among carriers of the *1F allele. The corresponding ORs (95% CIs) for those with the *1A/*1A genotype were 1.00, 0.48 (0.26-0.87), 0.57 (0.35-0.95), and 0.83 (0.46-1.51).



    Conclusion Intake of coffee was associated with an increased risk of nonfatal MI only among individuals with slow caffeine metabolism, suggesting that caffeine plays a role in this association.





    Author Affiliations: Department of Nutritional Sciences, University of Toronto, Toronto, Ontario (Ms Cornelis and Dr El-Sohemy); Department of Nutrition, Harvard School of Public Health, Boston, Mass (Drs Kabagambe and Campos); and Centro Centroamericano de Poblacion, Universidad de Costa Rica, San Pedro de Montes de Oca, Costa Rica (Dr Campos).
    I`m not a girl, not yet a woman.

  2. #2
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    This means that some of us are suspectable to slower caffeine clearance from the blood, subsequent SNS overactivation and CV diseases. Do you have the full text with any numbes of how widespread the 1F/1F is?
    Man on a mission

  3. #3
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    In European populations homozygous mutant genotype (1F/1F) was found in 10% of those tested.



    http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=762551



    Nasty mutation that increases risk to colorectal cancer (1) as well as myocardial infarction (2) yet decreases the risk for breast cancer (3).







    (1) Cancer Lett. 2005 Nov 8;229(1):25-31.

    The CYP1A2-164A-->C polymorphism (CYP1A2*1F) is associated with the risk for colorectal adenomas in humans.



    (2) J Med Genet. 2004 Oct;41(10):758-62.

    Genetic polymorphism of CYP1A2 increases the risk of myocardial infarction.



    (3) Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):1998-2003.

    Estrogen metabolism-related genes and breast cancer risk: the multiethnic cohort study.

    Le Marchand L, Donlon T, Kolonel LN, Henderson BE, Wilkens LR.

  4. #4
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    Quote Originally Posted by liorrh' post='329709' date='Apr 30 2006, 01:54 PM

    This means that some of us are suspectable to slower caffeine clearance from the blood, subsequent SNS overactivation and CV diseases. Do you have the full text with any numbes of how widespread the 1F/1F is?


    It does not say in the article.



    An OR of 2.33 is pretty fucked up.
    I`m not a girl, not yet a woman.

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