Dianabol
Hi-Tech

Dianabol by Hi-Tech
Dianabol was designed to create a highly anabolic and anti-proteolytic growth environment that aggressively keeps acquired intramuscular protein intact and, as a powerful anabolic agent, increases protein synthesis and nitrogen retention.

Supplement Facts:
Serving Size 1 Tablet
Servings Per Container 90

Amount Per Serving % Daily Value
Proprietary Blend With Explotab® And Extend-Rx™ Technology: 575mg †
Belizian Man Vine Extract 80% (As BMV80™)(Root), Tribulus Terrestris (90% Steroidal Saponins)(Fruit), 25R Spirostan-5A-Diol-6-One-3-One, Dehydroepiandrosterone Acetate, Dehydroepiandrosterone Deconate, Phytosterol 90% Extract (Standardized For Beta-Sitosterol, Campesterol, Stigmasterol, Brassicasterol), Belizian Wild Yam Extract (As BWY 6015™), Ribonucleic Acid Complex 3™ (Ribosomal RNA, Transfer RNA, Messenger RNA), 7-Keto DHEA, 6,7 Dihydroxybergamottin, Naringen, Vanadyl Sulfate Ethyl Ester, Smilagenin, Dicyclopentanone.

Other Ingredients: Microcrystalline Cellulose, Dextrose, Sodium Starch Glycolate, Explotab® Hydroxy Propylmethylcellulose, Magnesium Stearate, Stearic Acid, Silica, FD&C Blue #1, FD&C Red #40

Directions: Take one (1) tablet three times daily with meals. This is important as the strength of this product can cause nausea if consumed without eating.

I fail to see where the magic bullet is within this compilation of ingredients. The company is claiming outstanding results can be attained from the "Anabolic Trifecta."
I guess I will remain agnostic, unless I am proven wrong via my experiences with this stack.

Explanation of Ingredients:
I have provided brief explanations of what the ingredients are.
I am not responsible for the veracity of these statements.
A link is underneath all excerpts, indicating where it is derived from.

Belizian Man Vine Extract 80% (As BMV80™)(Root)
Not much information is available. It appears to be a mish mash of phytosterols with some DHEA
Metabolites.

Tribulus Terrestris (90% Steroidal Saponins)(Fruit)
Cultivation and uses
The plant is widely naturalised in the Americas and also in Australia south of its native range. In some states in the United States, it is considered an invasive species.[3]
It has been reported that puncture vine seeds have been used in homicidal weapons in southern Africa; murderers smear them with the poisonous juice of Acokanthera venenata and put them where victims are likely to step.[4]
Dietary supplement
Tribulus terrestris has long been a constituent in tonics in Indian ayurveda practice, where it is known by its Sanskrit name, "gokshura."[5]It is now being promoted as a booster for the purpose of increasing sex drive. Its use for this purpose originated in Eastern Europe in the 1970's. Independent studies [6] have suggested that Tribulus terrestris extract slightly increases hormone levels, though leaving them in the normal range.
Some have compared the tonic properties of Tribulus terrestris to the effects of ginseng, but these occur due to entirely different mechanisms. It is also claimed that Tribulus terrestris increases testosterone by increasing gonadotropin-releasing hormone[7] (GnRH) which in turn stimulates the production of LH and follicle-stimulating hormone (FSH). Testosterone, besides its role in muscle-building and raising fertility and libido, is also known to have a positive effect on bone marrow activity (for red blood cell production) and the immune system.[citation needed]
On the other hand, one recent study found that T. terrestris caused no increase in testosterone or LH in young men,[8] and another found that a commercial supplement containing androstenedione and herbal extracts, including T. terrestris, was no more effective at raising testosterone levels than androstenedione alone.[9] a cousin to DHEA. In a study with mice, Tribulus was shown to enhance mounting activity and erection better than testosterone cypionate.[citation needed] This however, isn't as convincing as one might think. Although an OTC supplement outpacing a pharmaceutical is big news, testosterone cypionate is a synthetic ester of testosterone engineered for its longer activity. To be effective, its level must build up in the system of the animal using it. This process usually takes 2–3 weeks.National Institutes of Health, <http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=2268>. Retrieved on 15 November 2007 The proerectile aphrodisiac properties were concluded to likely be due to the release of nitric oxide from the nerve endings innervating the corpus cavernosum penis.
No significant adverse effects have been reported from supplementation with Tribulus terrestris. However, some users report an upset stomach, which can usually be counteracted by taking it with food.[6]
http://en.wikipedia.org/wiki/Tribulus_terrestris


25R Spirostan-5A-Diol-6-One-3-One
I believe the compound in Anavar is the 6-keto version of this compound. The 6-Keto is a primary oxidative metabolite of 25R-diol. 25R-diol has more activity on it's own with the same or better benefits and a longer active half-life.
This may or may not be similar to the ingredient in MassFX
“Big Smith”
http://anabolicminds.com/forum/anabolic-xt...ss-fx-high.html

Dehydroepiandrosterone
Acetate
Deconate
Dehydroepiandrosterone (DHEA) is a natural steroid prohormone produced from cholesterol by the adrenal glands, the gonads, adipose tissue, brain and in the skin (by an autocrine mechanism). DHEA is the precursor of androstenedione, which can undergo further conversion to produce the androgen testosterone and the estrogens estrone and estradiol. DHEA is also a potent sigma-1 agonist.[1]
Studies have shown that DHEA is useful in patients with systemic lupus erythematosus. An application of the evidence was discussed by the U.S. Food and Drug Administration in 2001 and is available online.[2] This review also shows that cholesterol and other serum lipids decrease with the use of DHEA (mainly a decrease in HDL-C and triglycerides can be expected in women, p110).
DHEA supplementation has been studied as a treatment for Alzheimer's disease, but was found to be ineffective.[3] Some small placebo-controlled randomized clinical trial studies have found long-term supplementation to improve mood and relieve depression[4][5] or to decrease insulin resistance.[6] However, a larger placebo-controlled randomized clinical trial reported in the New England Journal of Medicine in 2006 found that DHEA supplementation in elderly men and women had no beneficial effects on body composition, physical performance, insulin sensitivity, or quality of life.[7]
DHEA supplements are sometimes used as muscle-building or performance-enhancing drugs by athletes. However, a randomized placebo-controlled trial found that DHEA supplementation had no effect on lean body mass, strength, or testosterone levels.[8]
A 1986 study found that a higher level of endogenous DHEA, as determined by a single measurement, correlated with a lower risk of death or cardiovascular disease.[9] However, a more recent 2006 study found no correlation between DHEA levels and risk of cardiovascular disease or death in men.[10] A 2007 study found the DHEA restored oxidative balance in diabetic patients, reducing tissue levels of pentosidine—a biomarker for advanced glycation endproducts.[11]
Some in vitro studies have found DHEA to have an anti-proliferative or apoptotic effect on cancer cell lines.[12][13][14] The clinical significance of these findings, if any, is unknown. Higher levels of DHEA, in fact, have been correlated with an increased risk of developing breast cancer in both pre- and postmenopausal women.[15][16]
A 2002 review found that DHEA was difficult to study in an animal model. The authors concluded that there was no evidence that DHEA was beneficial for any of the conditions for which it had been studied to that point, that it was associated with significant side effects, and that based on these findings, "there is currently no scientific reason to prescribe DHEA for any purpose whatsoever."[17]
http://en.wikipedia.org/wiki/Dehydroepiandrosterone


Phytosterol 90% Extract (Standardized For Beta-Sitosterol, Campesterol, Stigmasterol, Brassicasterol)
Phytosterols (also called plant sterols) are a group of steroid alcohols, phytochemicals naturally occurring in plants. They are white powders with mild, characteristic odor, insoluble in water and soluble in alcohols. They have many applications as food additives, and in medicine and cosmetics.
http://en.wikipedia.org/wiki/Phytosterol

Belizian Wild Yam Extract (As BWY 6015™)
Wild yam has both essence building power and an astringent action that preventing "leaking" of fluids. It is widely recommended for the "leakage" problems, such as spermatorrhea [nocturnal emission], leukorrhea and frequent urination. It is also often used by people suffering night sweats as a result of general weakness or chronic consumptive illness. Dioscorea will help strengthen the back and knees. Diabetes is a disorder for which Dioscorea is very highly recommended in Asia.
Action:
1) It is a remedy used to relieve intestinal colic, to soothe diverticulitis, ease dysmenorrhoea and ovarian and uterine pains.
2) It is also used in the treatment of rheumatoid arthritis, especially the acute phase where there is intense inflammation.
http://www.21food.com/offerdetail/84969/Wi...am-Extract.html

Ribonucleic Acid Complex 3™ (Ribosomal RNA, Transfer RNA, Messenger RNA)
Lack of available Information.

7-Keto DHEA
DHEA is a steroid produced by the adrenal gland7 and is the most abundant steroid in human blood8. There are always two things you should understand prior to the use of any sport / health supplement.
1. Safety of the product and the dose range proven to be safe.
2. Knowledge of how the supplement is taken up into the tissues and how quick it is excreted, "in-essence it's pharmacokinetic profile".
7-keto is a highly active derivative of DHEA and is one supplement of which its pharmacokinetic profile is needed if we want to ascertain when peak levels occur in plasma. This information will help prescribe the best possible rational for its time of use, dosage, and safety to optimise body compositional changes.
A series of trials have looked at both the safety and pharmacokinetics of 7-keto (see Fig. 2 below.). In animal studies, 7-Keto was shown to be safe and in effect non-toxic to levels of 2000mg/kg in rats9 and 1000mg/kg in monkeys10. Toxicity was assessed by full-blood chemistry, blood cell counts and histological examination in 42 different tissues. Again caution must be taken until we see the human data; so what human data does exist? Davidson et al11 studied a series of doses ranging from 50mg/d (25mg twice daily) for 7 days; 100mg/d (50mg twice daily) for 7 days; and finally 200mg/d (100mg twice for 28 days). Results demonstrated that at all doses, 7-keto in comparison to a placebo presented no substantial impact on clinical blood markers of toxicity and health. This data was supported in further human trials12-13.
http://www.bodybuilding.com/store/7keto.html

6,7 Dihydroxybergamottin
BACKGROUND: 6',7'-Dihydroxybergamottin is a furanocoumarin that inhibits CYP3A4 and is found in grapefruit juice and Seville orange juice. Grapefruit juice increases the oral bioavailability of many CYP3A4 substrates, including cyclosporine (INN, ciclosporin), but intestinal P-glycoprotein may be a more important determinant of cyclosporine availability. OBJECTIVES: To evaluate the contribution of 6',7'-dihydroxybergamottin to the effects of grapefruit juice on cyclosporine disposition and to assess the role of CYP3A4 versus P-glycoprotein in this interaction. METHODS: The disposition of oral cyclosporine was compared in healthy subjects after ingestion of water, grapefruit juice, and Seville orange juice. Enterocyte concentrations of CYP3A4 were measured in 2 individuals before and after treatment with Seville orange juice. The effect of 6',7'-dihydroxybergamottin on P-glycoprotein was assessed in vitro. RESULTS: Area under the whole blood concentration-time curve and peak concentration of cyclosporine were increased by 55% and 35%, respectively, with grapefruit juice (P < .05). Seville orange juice had no influence on cyclosporine disposition but reduced enterocyte concentrations of CYP3A4 by an average of 40%. 6',7'-Dihydroxybergamottin did not inhibit P-glycoprotein at concentrations up to 50 micromol/L. CONCLUSIONS: 6',7'-Dihydroxybergamottin is not responsible for the effects of grapefruit juice on cyclosporine. Because the interaction did not occur with Seville orange juice despite reduced enterocyte concentrations of CYP3A4, inhibition of P-glycoprotein activity by other compounds in grapefruit juice may be responsible. Reduced enterocyte CYP3A4 by 6',7'-dihydroxybergamottin could be important for other drugs whose bioavailability is less dependent on P-glycoprotein.

Naringen
Naringin is the major flavonoid glycoside in grapefruit and gives grapefruit juice its bitter taste. It is metabolized to the flavanone naringenin in humans. Both naringenin and hesperetin, which are the aglycones of naringin and hesperidin, occur naturally in citrus fruits.
Narinigin exerts a variety of pharmacological effects such as antioxidant activity, blood lipid-lowering, anticarcinogenic activity, and inhibition of selected cytochrome P450 enzymes including CYP3A4 and CYP1A2, which may result in several drug interactions in-vitro.[1]
http://en.wikipedia.org/wiki/Naringin

Naringen is a citrus flavanoid commonly found in grapefruit, and is responsible for grapefruit's distinctive bitter taste. Most of us have heard how it's important to be careful consuming grapefruit juice along with certain medications studies reveal that naringen interferes with some digestive enzymes which can affect the metabolism and breakdown of these drugs. This can in effect lead to an inadvertantly higher dose of the drug, which may pose the threat of adverse reactions in some cases.
However, naringen displays many other interesting properties, some of which make it suitable for inclusion into the ingredients list of many popular fat burners.
For one, there is some evidence that the effects and levels of caffeine can be extended when consumed with naringen. Since virtually 99% of the fat burners on the market contain caffeine (often derived from natural sources like Kola nut, Yerba mate, Green tea, and so on), and since caffeine does exhibit thermogenic (fat burning) properties, naringen is an obvious way to improve and extend its effects.
Naringen has also been shown to exhibit cholesterol-lowering effects which is always a good thing for dieters. It's also an aldose reductase inhibitor, which means it may also have a role to play battling retinal disease in diabetics.
http://www.247weight.com/naringen.htm

Vanadyl Sulfate Ethyl Ester
Vanadyl(IV) sulfate, VOSO4, is a blue crystalline solid that is normally stable in room conditions. It is a moderately strong reducing agent, being oxidized in acidic solution to the vanadyl(V) ion and in alkaline solutions to the vanadate ion, both of which are yellow-orange in colour. It is reduced by zinc amalgam to a mixture of green vanadium(III) and purple vanadium(II) ions. It is also used in conjunction with chromium picolinate in a sugar blocker. Here it is said to improve blood sugar levels, and thereby increase energy, although these statements have not been evaluated by the FDA.
http://en.wikipedia.org/wiki/Vanadium(IV)_sulfate

Athletes have long used vanadyl sulfate to increase their performance. It is believed to play a role in helping to regulate the body's healthy blood sugar levels, similar to insulin. Studies show that vanadyl sulfate mainly helps the muscle cells uptake glucose (instead of fat cells (adipocytes) uptaking glucose). Basically, by mimicking the actions of insulin, vanadyl sulfate forces more proteins, amino acids, and carbohydrates directly into muscles. Vanadyl sulfate is an awesome, popular supplement that seems to work for building better muscles; nevertheless, the scientific jury is still deliberating.
http://www.bodybuilding.com/store/van.html

Smilagenin
smilagenin (uncountable)
3. (organic chemistry) A derivative of sapogenin that is used medically to treat conginive dysfunction
Retrieved from "http://en.wiktionary.org/wiki/smilagenin"

What is claimed is:
1. A method enhancing cognitive function in a human or non-human animal,
which comprises administering an effective dose of smilagenin.
2. A method of enhancing cognitive function in a patient suffering from
age-related cognitive dysfunction, which comprises administering to the
patient a pharmacologically effective dose of smilagenin.
3. A method as claimed in claim 1, which is for the treatment of
Alzheimer's disease or a senile dementia of the Alzheimer's type.
4. A method as claimed in claim 2, which is for the treatment of
Alzheimer’s Disease or a senile dementia of the Alzheimer's type.
5. A method according to claim 1 which comprises administering a foodstuff
or beverage containing an effective dosage of smilagenin.
6. A method as claimed in claim 1 wherein smilagenin is administered in the
form of a pharmaeutical composition.
7. A method as defined in claim 1 wherein smilagenin is administered in the
form of a pharmacologically effective amount of smilagenin in the form of
an extract derived from a plant of the genus Smilax, asparagus,
Anemarrhena, Yucca or Agave.
8. A method as defined in claim 1 wherein a dosage effective to enhance
cognitive function is administered to a person suffering from loss of
cognitive function.
http://www.patentstorm.us/patents/6258386/claims.html

Dicyclopentanone

[Anabolic activity of some dicyclopentanone derivatives]
[Article in Russian]
Mel'nikova TA, Mel'nik SI.
Anabolic activity of 1,5-bis(1-carbethoxy-2-oxocyclopentyl-1) pentane in a dose of 1 mg per 100 g of body weight manifests itself in an accelerated growth of the animals, increased weight of m. levator ani and also in a rise of the protein level in the blood and the skeletal muscle. Because of the absence of androgenic properties in the substance under consideration its anabolic coefficient is twice as high by comparison with methylandrostendiol. Following hypophysectomy there could be observed a certain decline in the anabolic activity of 1,5-bis(1-carbethoxy-2-oxocyclopentyl-1)pentane.
PMID: 1227920 [PubMed - indexed for MEDLINE]
Thankyou, blackdream71 for posting this on BB.com