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Modafinil

Posted 23 October 2009 - 02:13 PM (#1) User is offline   john410 

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Hey guys.

I'm diagnosed with ADD/Depression. After doing the whole med-go-round (SSRIs, Ritalin, Bupropion), I'm currently on deprenyl and although it's better than nothing I still need something more.

I'm a "third world monkey" (Par Deus), so no Adderall around here for me to take MOAR. Just plain old school Ritalin, Concerta (expensive as FUCK!), and Modafinil, which has just arrived around here.

What do you guys think about Modafinil? Does anyone knows exactly how it works?

As always, thanks!
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Posted 25 October 2009 - 12:54 AM (#2) User is online   DavidWebb 

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overrated for ADD applications, but effective for long drives and 12+ hour bombing/surveillance missions above afghanistan.
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Posted 25 October 2009 - 02:11 AM (#3) User is offline   Sanction 

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QUOTE (DavidWebb @ Oct 24 2009, 10:54 PM) <{POST_SNAPBACK}>
overrated for ADD applications, but effective for long drives and 12+ hour bombing/surveillance missions above afghanistan.

Which means that it will keep you awake but not necessarily attentive or happy.
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Posted 25 October 2009 - 11:13 AM (#4) User is offline   john410 

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any other suggestions?
QUOTE (Frangible @ Sep 14 2009, 06:18 PM) <{POST_SNAPBACK}>
Yes... welcome to M&M, now quit with the Timothy Learyisms, names involving "flower", and start juicing, son.
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Posted 25 October 2009 - 12:09 PM (#5) User is online   Benson 

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QUOTE (john410 @ Oct 23 2009, 03:13 PM) <{POST_SNAPBACK}>
I'm a "third world monkey" (Par Deus), so no Adderall around here for me to take MOAR. Just plain old school Ritalin, Concerta (expensive as FUCK!), and Modafinil, which has just arrived around here.


No dexadrine spansules in your banana republic?

However beautiful the strategy, you should occasionally look at the results... - Winston Churchill
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Posted 25 October 2009 - 01:58 PM (#6) User is online   Chaos Theory 

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Modafinil definitely helped my concentration, but that effect wore off within a month. Long-term, modafinil only seemed good at compensating for the sleep loss that it caused me. When I was using it daily I never slept more than six hours, and every morning when I woke up I felt wide awake instantly. It definitely had some kind of effect on my sleep structure. Very low dose deprenyl has been better for ADHD in my experience.
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Posted 25 October 2009 - 04:19 PM (#7) User is offline   john410 

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QUOTE (Chaos Theory @ Oct 25 2009, 04:58 PM) <{POST_SNAPBACK}>
Modafinil definitely helped my concentration, but that effect wore off within a month. Long-term, modafinil only seemed good at compensating for the sleep loss that it caused me. When I was using it daily I never slept more than six hours, and every morning when I woke up I felt wide awake instantly. It definitely had some kind of effect on my sleep structure. Very low dose deprenyl has been better for ADHD in my experience.


very low dose deprenyl equals how much in your experience?

I was taking 7.5mg, then down to 5mg. I'm on 2.5mg now, but I've started this dosage just today.
QUOTE (Frangible @ Sep 14 2009, 06:18 PM) <{POST_SNAPBACK}>
Yes... welcome to M&M, now quit with the Timothy Learyisms, names involving "flower", and start juicing, son.
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Posted 25 October 2009 - 04:23 PM (#8) User is offline   john410 

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QUOTE (Benson @ Oct 25 2009, 03:09 PM) <{POST_SNAPBACK}>
No dexadrine spansules in your banana republic?


Unfortunately, no.

just Ritalin, Concerta and now Modafinil.


QUOTE (Frangible @ Sep 14 2009, 06:18 PM) <{POST_SNAPBACK}>
Yes... welcome to M&M, now quit with the Timothy Learyisms, names involving "flower", and start juicing, son.
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Posted 25 October 2009 - 05:09 PM (#9) User is offline   keninishna 

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QUOTE (Chaos Theory @ Oct 25 2009, 02:58 PM) <{POST_SNAPBACK}>
Modafinil definitely helped my concentration, but that effect wore off within a month. Long-term, modafinil only seemed good at compensating for the sleep loss that it caused me. When I was using it daily I never slept more than six hours, and every morning when I woke up I felt wide awake instantly. It definitely had some kind of effect on my sleep structure. Very low dose deprenyl has been better for ADHD in my experience.


My experience is very similar. I liked taking about 2.5 mg deprenyl a week. Even that though wore off after about a month. Im starting to think a lot of ADD is just caused by bad sleep habits and poor coping skills along with anxiety.
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Posted 25 October 2009 - 06:23 PM (#10) User is online   Benson 

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QUOTE (john410 @ Oct 25 2009, 05:23 PM) <{POST_SNAPBACK}>
Unfortunately, no.

just Ritalin, Concerta and now Modafinil.



Where the heck do you live? The moon?

However beautiful the strategy, you should occasionally look at the results... - Winston Churchill
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Posted 26 October 2009 - 03:56 AM (#11) User is offline   avantgarde 

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QUOTE (Benson @ Oct 25 2009, 03:23 PM) <{POST_SNAPBACK}>
Where the heck do you live? The moon?


laugh.gif

For the record, amphetamine is pretty much only widely prescribed in the U.S.

EU and most of Asia are shit out of luck (although UK might be somewhat better).

I live in an EU country and managed to get dexamphetamine only after a very lenghty licence ordeal (99 % of patients get Concerta/Ritalin or Strattera).

Oh and no Spansules here either only IR.




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Posted 26 October 2009 - 11:37 PM (#12) User is online   Chaos Theory 

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QUOTE (john410 @ Oct 25 2009, 05:19 PM) <{POST_SNAPBACK}>
very low dose deprenyl equals how much in your experience?

I was taking 7.5mg, then down to 5mg. I'm on 2.5mg now, but I've started this dosage just today.

I seem to do better on 1.25mg - 2.5mg once in the morning. It's deceiving because there is really no acute effect anymore after you have been taking it daily for a long time. I found out it was working when I took a few days off and suddenly couldn't focus on shit anymore.

QUOTE (keninishna @ Oct 25 2009, 06:09 PM) <{POST_SNAPBACK}>
My experience is very similar. I liked taking about 2.5 mg deprenyl a week. Even that though wore off after about a month. Im starting to think a lot of ADD is just caused by bad sleep habits and poor coping skills along with anxiety.

I've said it before on here. The deprenyl definitely helps, but everything else in my life has to be in order. In order of importance those things would be sleep, diet, and enough exercise.
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Posted 27 October 2009 - 12:43 AM (#13) User is online   DavidWebb 

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QUOTE (Chaos Theory @ Oct 27 2009, 12:37 AM) <{POST_SNAPBACK}>
I seem to do better on 1.25mg - 2.5mg once in the morning. It's deceiving because there is really no acute effect anymore after you have been taking it daily for a long time. I found out it was working when I took a few days off and suddenly couldn't focus on shit anymore.


I've said it before on here. The deprenyl definitely helps, but everything else in my life has to be in order. In order of importance those things would be sleep, diet, and enough exercise.


I assume you are taking it after a meal?
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Posted 27 October 2009 - 07:47 PM (#14) User is online   Chaos Theory 

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QUOTE (DavidWebb @ Oct 27 2009, 01:43 AM) <{POST_SNAPBACK}>
I assume you are taking it after a meal?

I do take it after a small meal, protein shake and some oatmeal in the morning. I don't actually swallow it though. I keep it under my tongue until it's completely dissolved. I don't have the sublingual tabs but they still break down very easily.
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Posted 13 July 2010 - 10:28 AM (#15) User is offline   john410 

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QUOTE (Benson @ Oct 25 2009, 08:23 PM) <{POST_SNAPBACK}>
Where the heck do you live? The moon?


LOL.

I'm from Brazil.

Bumping an old thread to report...

I'm having some success with Methylphenidate and Modafinil. I'm taking 7,5mg of Ritalin (4x/day, spaced in 4-hour intervals) and 100mg of Modafinil (in the morning with my first methylphenidate dose).

5mg of methylphenidate isn't enough for focus. if I try 10mg, I feel sleeeeeeeeeeepy.

I'm thinking about dropping Modafinil even lower (50mg) because of some spacey feeling I'm getting randomly. They were more severe at 200mg. At 300mg I was bordering psychosis. That's why I think it's the Modafinil.

I miss the sexual urge I got on higher dosages of Modafinil. On the other hand, it isn't nice if all you want is bang women all the time and can't do other things.

Does anyone here have any experiences on lower doses of Modafinil?
QUOTE (Frangible @ Sep 14 2009, 06:18 PM) <{POST_SNAPBACK}>
Yes... welcome to M&M, now quit with the Timothy Learyisms, names involving "flower", and start juicing, son.
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Posted 13 July 2010 - 03:41 PM (#16) User is offline   chriswhat 

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I only use 50mg of modafinil at a time. It makes me too jittery. To the poster that is taking deprenyl I believe there are some very dangerous drug interactions between it and any amphetamines/modafinil. Dangerous as in death. I was looking at using both at one time.
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Posted 13 July 2010 - 07:50 PM (#17) User is offline   Dopamine 

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QUOTE (chriswhat @ Jul 13 2010, 03:41 PM) <{POST_SNAPBACK}>
I only use 50mg of modafinil at a time. It makes me too jittery. To the poster that is taking deprenyl I believe there are some very dangerous drug interactions between it and any amphetamines/modafinil. Dangerous as in death. I was looking at using both at one time.


Theoretically, there is potential for interaction, but the affinity of modafinil for DAT is relatively low compared to amphetamine. I've combined the two before without problems (YMMV). I agree with your note of caution though.

As to the OP, Modafinil was really, really close to being approved for treatment of ADD/ADHD in the U.S., but was ditched by the FDA over concerns around development of Steven Johnson's syndrome in children. Not much of a concern for adults though, since kids need about as much as adults to reach effectiveness, but with much higher mg/kg dosing range (ages 6-17 dose at around 170-425mg).

But remember kids, just 'cause a drug is a stimulant and effectively treats ADD/ADHD, doesn't mean it will feel (at all) like amphetamine.
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Posted 13 July 2010 - 08:40 PM (#18) User is offline   john410 

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QUOTE (Dopamine @ Jul 13 2010, 09:50 PM) <{POST_SNAPBACK}>
Theoretically, there is potential for interaction, but the affinity of modafinil for DAT is relatively low compared to amphetamine. I've combined the two before without problems (YMMV). I agree with your note of caution though.

As to the OP, Modafinil was really, really close to being approved for treatment of ADD/ADHD in the U.S., but was ditched by the FDA over concerns around development of Steven Johnson's syndrome in children. Not much of a concern for adults though, since kids need about as much as adults to reach effectiveness, but with much higher mg/kg dosing range (ages 6-17 dose at around 170-425mg).

But remember kids, just 'cause a drug is a stimulant and effectively treats ADD/ADHD, doesn't mean it will feel (at all) like amphetamine.


hey Dopamine...

what dose do you use to treat ADD?

Modafinil alone:
For me, 300mg was too much. stomach pains, diarrhea, and feeling/acting a little bit weird to say the least.

200mg... well... my focus wasn't improved. And I had some sides too, felt spacey.

On both dosages I was yawning all day long. It started around T+3 and lasted the entire day.

can't comment on 100mg, because I started that dosage when I decided to add the Ritalin to the combo.
QUOTE (Frangible @ Sep 14 2009, 06:18 PM) <{POST_SNAPBACK}>
Yes... welcome to M&M, now quit with the Timothy Learyisms, names involving "flower", and start juicing, son.
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Posted 14 July 2010 - 12:16 AM (#19) User is offline   Dopamine 

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QUOTE (john410 @ Jul 13 2010, 08:40 PM) <{POST_SNAPBACK}>
hey Dopamine...

what dose do you use to treat ADD?

Modafinil alone:
For me, 300mg was too much. stomach pains, diarrhea, and feeling/acting a little bit weird to say the least.

200mg... well... my focus wasn't improved. And I had some sides too, felt spacey.

On both dosages I was yawning all day long. It started around T+3 and lasted the entire day.

can't comment on 100mg, because I started that dosage when I decided to add the Ritalin to the combo.


For adult ADD/ADHD - one 200mg dose upon rising, allowing 20-30 minutes before ingesting any food, consistently for at least 3 weeks. If side effects arise, split the dose into two 100mg doses, one at rising and the other in the early to middle afternoon.

Remember that rapidly fluctuating your dosage will dramatically decrease the likelihood of successful treatment.
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Posted 14 July 2010 - 08:29 AM (#20) User is online   morganator 

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I hated provigil. Maybe I should have tried an unusually low dose. It destabilized me making me feel agitated and a bit dysphoric. It was not a good time in my life though, that may have had something to do with my reaction.
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Posted 14 July 2010 - 09:38 AM (#21) User is online   FunkOdyssey 

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I always felt pretty good on modafinil. I think I stopped taking it because some posters on ImmInst were complaining of cognitive problems after several months of use. I've been thinking about trying it again after my new criteria of no-potential-immunosuppression disqualified every other activating/stimulating psychoactive drug (yes even caffeine).
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Posted 15 July 2010 - 07:21 PM (#22) User is offline   Dopamine 

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John410 - I saw your post about the 50mg dose and it has been used successfully in one case report that comes to mind from Robert C. Bransfield, MD. "Potential Uses of Modafinil in Psychiatric Disorders," The Journal of Applied Research Vol. 4 (2), 2004 (link). See Case 3 "Ms G" pp. 204.
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Posted 15 July 2010 - 07:44 PM (#23) User is online   FunkOdyssey 

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QUOTE (Dopamine @ Jul 15 2010, 08:21 PM) <{POST_SNAPBACK}>
John410 - I saw your post about the 50mg dose and it has been used successfully in one case report that comes to mind from Robert C. Bransfield, MD. "Potential Uses of Modafinil in Psychiatric Disorders," The Journal of Applied Research Vol. 4 (2), 2004 (link). See Case 3 "Ms G" pp. 204.


BTW, that is the President of ILADS and the author of this presentation I just posted on the forum a couple days ago:

Infectious causes of psychiatric disorders and treatment

He likes modafinil during the day and pregabalin at night to normalize amplitude of circadian rhythm in patients with disturbed sleep and poor daytime functioning.
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