[Frangible]

Brotelligence anecdote time, yo.

I just tried eating some beef jerky, a manly snack if there ever was one, when after like two bites (which were well-chewed) I started to feel the typical choking sensations and excess mucous production that you usually see with food allergies involving the immune system shitting a giant histamine brick.

Well, it wasn't full-on anaphylactic shock, but my breathing was impaired. Attempts at inducing vomiting yielded no food material, just about 8 tons of mucous. Usually, when this happens I just wait a while and try to drink something and everything's usually fine. But it wasn't resolving in this case, with even some fine Mexican Coke not resolving the situation. (and by that I mean the shit Costco sells in the winnar glass bottles)

I figured the main problem was the mucous production, which I was gagging on (seriously, how does the body make this shit so quickly?) Unfortunately my first-line anti-ACh, diphenhydramine, was an oral drug, and I wasn't sure about mucous membrane absorption.

So, out of desperation of the problem almost seeming to get worse due to my body somehow pulling 8 gallons of mucous from a parallel universe or something, I busted out the oxymetazoline inhaler (which I do NOT regularly use), and within seconds things were significantly better.

I also tried, in direct violation of the directions and likely the Geneva Conventions, spraying the shit directly into the back of my mouth while saying "ahhhh". This helped even further, and I could soon drink fluids and have them flow normally. The excess mucous secretion was almost completely gone.

But I'm not sure why this worked. I can't see anything on PubMed about alpha-2a agonists helping anything outside of nasal tissue at all. Theoretically, the vasoconstriction buys you a little volume, but this seemed like it was significantly more.

Supposedly it alpha-2a activation can have effects on decreasing ACh release, but is that really significant/so rapid?

On a sidenote, I also have tonsilar hypertrophy after a recent sinus infection that migrated to the tonsils, which probably gives me less volume to work with than normal (yeah, have a surgery consult scheduled). Still, the upper tonsils weren't causing any problems I could see, and it felt like the problem was at least 5" down my throat.

Anyway, not saying anyone should dump their EpiPen, but if your immune system ever shits brix and you're gagging on something, try giving it a shot... if anyone has a better idea of the mechanism of action, especially in halting mucous production so rapidly, I'd love to hear it.

(I do not notice any decrease in mucous production with pseudoephedrine which also binds to a1a/a2a receptors)

[Ex Dubio]

Brotelligence anecdote time, yo.

I just tried eating some beef jerky, a manly snack if there ever was one, when after like two bites (which were well-chewed) I started to feel the typical choking sensations and excess mucous production that you usually see with food allergies involving the immune system shitting a giant histamine brick.

Well, it wasn't full-on anaphylactic shock, but my breathing was impaired. Attempts at inducing vomiting yielded no food material, just about 8 tons of mucous. Usually, when this happens I just wait a while and try to drink something and everything's usually fine. But it wasn't resolving in this case, with even some fine Mexican Coke not resolving the situation. (and by that I mean the shit Costco sells in the winnar glass bottles)

I figured the main problem was the mucous production, which I was gagging on (seriously, how does the body make this shit so quickly?) Unfortunately my first-line anti-ACh, diphenhydramine, was an oral drug, and I wasn't sure about mucous membrane absorption.

So, out of desperation of the problem almost seeming to get worse due to my body somehow pulling 8 gallons of mucous from a parallel universe or something, I busted out the oxymetazoline inhaler (which I do NOT regularly use), and within seconds things were significantly better.

I also tried, in direct violation of the directions and likely the Geneva Conventions, spraying the shit directly into the back of my mouth while saying "ahhhh". This helped even further, and I could soon drink fluids and have them flow normally. The excess mucous secretion was almost completely gone.

But I'm not sure why this worked. I can't see anything on PubMed about alpha-2a agonists helping anything outside of nasal tissue at all. Theoretically, the vasoconstriction buys you a little volume, but this seemed like it was significantly more.

Supposedly it alpha-2a activation can have effects on decreasing ACh release, but is that really significant/so rapid?

On a sidenote, I also have tonsilar hypertrophy after a recent sinus infection that migrated to the tonsils, which probably gives me less volume to work with than normal (yeah, have a surgery consult scheduled). Still, the upper tonsils weren't causing any problems I could see, and it felt like the problem was at least 5" down my throat.

Anyway, not saying anyone should dump their EpiPen, but if your immune system ever shits brix and you're gagging on something, try giving it a shot... if anyone has a better idea of the mechanism of action, especially in halting mucous production so rapidly, I'd love to hear it.

(I do not notice any decrease in mucous production with pseudoephedrine which also binds to a1a/a2a receptors)

Gotta look for cites, but IIRC, this is massive, nearly instantaneous vasoconstriction due to alpha1/alpha2 agonism. A huge part of the histamine reaction is, of course, vasodilation to the affected region, so shutting that down will shut down any fluid-dependent processes. The physics certainly makes sense.

I'd be pretty surprised if it was the alpha2 activity that was purely responsible, especially given that oxymetazoline is a much stronger alpha1 agonist that alpha2 and given that phenylephrine (an alpha1 agonist) is also used as a decongestant. As for pseudoephedrine - it's not an alpha agonist (at least not enough to be worth mentioning). It's a sympathomimetic inducing the release of NE. But it is still subject to presynaptic alpha2 activation reducing NE output and is limited by the constraints on the endogenous NE system. Phenylephrine is, however, an alpha1 agonist, but the concentration of oxymetazoline that you achieved locally is probably much greater than with systemic phenylephrine administration.

[Benson]

As for pseudoephedrine - it's not an alpha agonist (at least not enough to be worth mentioning).

Isn't pseudo's alpha agonism what cinches up the bladder sphincter and causes issues for men with BPH?

[ozzman]

Have you figured out what it was that caused the allergic reaction?

[markog]

Oxymetazolne es la shit for stuffy nose/throat type stuff. but long term use WlLL DEF fuck up your nose. AKA permanant turbinate hyperplasia.

[Frangible]

Gotta look for cites, but IIRC, this is massive, nearly instantaneous vasoconstriction due to alpha1/alpha2 agonism. A huge part of the histamine reaction is, of course, vasodilation to the affected region, so shutting that down will shut down any fluid-dependent processes. The physics certainly makes sense.

Hmm, can't say I was too familiar with the mechanics of nasal mucous secretion, so if it's vasodilation that's responsible for the fuckton of mucous being dumped down my esophagus, I guess that makes sense.

(I once had bronchitis as a kid. I remember coughing up a good half-gallon+ of shit every day or so for like two weeks. THEN I got to go to the doctor, and Z-PACK just kicked in, yo)

Have you figured out what it was that caused the allergic reaction?

No. It's been random odd spices and shit in the past, nothing that shows up on your standard MELISA tests.

I think another possibility might be physical irritation of my hypertrophied tonsils, but I'm not sure, as hypertrophied tonsils are also hypersensitive in terms of immune reaction as well.

At any rate, I'll have a Final Solution to the Tonsil Question scheduled soon. Possibly involving lazers.

Oxymetazolne es la shit for stuffy nose/throat type stuff. but long term use WlLL DEF fuck up your nose. AKA permanant turbinate hyperplasia.

Yeah, long term use is not my goal, I save the oxy for special occasions.

[markog]

Frangy, you should give thls nigga a shot rite here.


http://www.neilmed.com/usa/index.php

Also do you use a steriod nasal spray or mucinex type products? Both help me somewhat.

Just not talking about food allergies just seasonal allergies ln general, which, unless Im mistaken you have also.