[Benson]

I have been watching a specific soy extract that is intended for menopause relief because in early studies, it seemed to have SERM-like effects.

This newer study from May seems to confirm that this stuff is a SERM and it might therefore have some use for PCT...its the active in a supplement called Femarelle.

J Steroid Biochem Mol Biol. 2007 May;104(3-5):252-8. Epub 2007 Mar 14
DT56a (Femarelle): a natural selective estrogen receptor modulator (SERM).
Somjen D, Katzburg S, Knoll E, Hendel D, Stern N, Kaye AM, Yoles I.

Institute of Endocrinology, Metabolism and Hypertension, Sourasky Medical Center, Tel-Aviv, Israel. dalias@tasmc.health.gov.il

A selective estrogen receptor modulator (SERM) is defined as a substance with dissimilar effects on different tissues: agonist in some and antagonists in others. The natural compound DT56a (Femarelle) was shown to activate estrogen receptors in human cultured female derived osteoblasts. It was also shown to relieve menopausal symptoms and to increase bone mineral density with no effect on sex steroid hormone levels and on the endometrial thickness. DT56a, similarly to estradiol-17beta (E2), stimulated the specific activity of creatine kinase (CK) in skeletal and vascular tissues of female rats, as a marker of estrogen receptor (ER) activation. However, in the uterus, CK was activated only by E2 but not by DT56a. In order to prove that DT56a is a SERM, we examined the mutual interaction between DT56a and E2, at supra physiological doses, in different tissues in both intact and ovariectomized female rats, as well as in human cultured vascular and bone cells. Administration of DT56a or E2 stimulated CK in all tissues tested, but when given simultaneously, in intact immature female rats, DT56a completely abolished E2 stimulation of CK in all organs except in the diaphyseal bone where the inhibition was partial. In ovariectomized female rats, DT56a abolished E2's stimulation of CK in diaphyseal bone, thymus, uterus and pituitary but caused a partial inhibition in aorta, left ventricle and epiphyseal cartilage. In human bone cells E2 stimulation of CK, of alkaline phosphatase (AP) activity and of DNA synthesis was completely abolished by DT56a in post-menopausal cells and partially inhibited in pre-menopausal cells. In human vascular cells, inhibition of DNA synthesis by E2 was completely abolished by DT56a and E2-induced CK was partially inhibited by DT56a. The results support the finding that DT56a is a SERM; it stimulated different parameters similar to E2, but when given simultaneously, at supra physiological doses, inhibited these E2's effects. Further investigations regarding intra and extra cellular mechanism of action of DT56a are currently performed.

PMID: 17428655

[D Sade]

too bad they didn't look at breast tissue.

[Benson]

D Sade, on Dec 8 2007, 09:00 AM, said:

too bad they didn't look at breast tissue.

Its not quite the same but it was non-stimulatory to cultured breast cancer cell lines PMID: 16580119

[D Sade]

Benson, on Dec 8 2007, 09:22 AM, said:

Its not quite the same but it was non-stimulatory to cultured breast cancer cell lines PMID: 16580119

Definitely a positive sign, then.

Need to find the actual compound name.

[Benson]

D Sade, on Dec 8 2007, 12:16 PM, said:

Definitely a positive sign, then.

Need to find the actual compound name.

I think its a proprietary soy extract.

[D Sade]

Benson, on Dec 8 2007, 10:37 AM, said:

I think its a proprietary soy extract.

Understood...but I highly doubt we can't figure it out.

I actually just had an idea of HOW to get it identified, as well as someone that could handle the extraction.

[rpen22]

So it's Tofu concentrate and Flaxseed?

 Tofupill_6pp.pdf (1.82MB)
Number of downloads: 5

[rpen22]

Oh, nevermind. DT56a is the name for the "unique tofu concentrate".

[nightop]

Its NOT OTC, its a dietary supplement! Benson, you disappoint.

[Benson]

nightop, on Dec 8 2007, 01:21 PM, said:

Its NOT OTC, its a dietary supplement! Benson, you disappoint.

Bah...point is you can purchase it without a script....but just for you I fixed the title...

[nightop]

Benson, on Dec 8 2007, 01:04 PM, said:

Bah...point is you can purchase it without a script....but just for you I fixed the title...

Thank you