I'm on Effexor and started Rhodiola a couple of weeks ago.The past week I've been having pretty severe headaches,mostly in the morning upon awakening,it was mostly centered in the back of my head.It goes away when I drink some coffee and take an aspirin.
Then I remebered reading something about Rhodiola sometimes causing headaches.I did a search on Animals board and came upon this post:
"rosea rhod is a maoi and comt inhibitor...whichs means stay away from it if you use ssri' or X.....
it is the herbal version of a "pressor" called phenylphrine....known as neosynephrine in the hospital....make sure you guys know what you are taking
Only 14 of the nearly 200 different Rhodiola species have been studied for biochemical activity. This species contains phenylpropanoids(PPA), proanthocyanidins and flavinoids...
It assists in the uptake of more intracellular calcium into the heart (a very vague statement)thus promoting a greater potential for heart muscle contraction. Rhodiola thus regulates the heart beat and counteracts heart arrhythmias.....
wow this is a huge jump in logic....anybody everhear of calcium channel blockers....so rosea is a positive ionotrope=makes the heart beat harder,,,which over a long time will lead to LVH
reputation for stimulating the nervous system, decreasing depression, enhancing work performance, eliminating fatigue, and preventing high altitude sickness
..so it is a stimulant
The adaptogenic, cardiopulmonary protective, and central nervous system activities of Rhodiola rosea have been attributed primarily to its ability to influence levels and activity of monoamines and opioid peptides such as beta-endorphins. so it is an adaptogen....it is cardiopulmonary protective....well you could call dobutamine an adaptogen then.....if you call all of the manifestations of chf a stress(Altern Med Rev 2001;6(3):293-302)
Rhodiola rosea has been intensively studied in Russia and Scandinavia for more than 35 years. Although the majority of this research on Rhodiola rosea is unavailable for review, available literature is supportive of its adaptogenic properties
...so most of the literature is not available...how convenient
Oral administration of a water extract of Rhodiola rosea to rats for 10 days modulated biogenic monoamines in the cerebral cortex, brain stem, and hypothalamus.
In the cerebral cortex and brain stem, levels of nor-epinephrine and dopamine decreased, while the amount of serotonin increased substantially.
In the hypothalamus, the results were reversed with a 3-fold increase in the amount of norepinephrine and dopamine, and a trend toward reduced serotonin levels.
It is believed these changes in monoamine levels are a result of Rhodiola rosea inhibiting the activity of the enzymes responsible for monoamine degradation, monoamine oxidase and catechol-O-methyltransferase.
...do you know how many contraindications MAOI's have....not to mention it blocks comt/moa...thus the breakdown of %20 catecholamine.......by the way...the sides of alpha agonists....anxiety, forceful heart beat, sever hypertension with extreme headache....and rebound nasal congestion
It is also believed Rhodiola rosea facilitates the transport of neurotransmitters within the brain.11
In addition to these central effects on monoamines, Rhodiola rosea has been reported to prevent both catecholamine release(hello it just said it raised catecholamines by MAOI COMTI, neg feedback induced inhibition of catecholamines....herbal man speak with forked tongue) and subsequent cAMP elevation in the myocardium, and the depletion of adrenal catecholamines induced by acute stress(most likely because they have already been released/negative feedback).12
so....this herb is like a natural dobutamine/phenylphrine..dobutamine is for the treatment of cardiac decompensation leading to acute congestive heart failure....phenylphrine is used in shock to increase map
also...anyone with hypertension or passed history HTN...dont take this...you will end up next to all the people that take ephedra on top of HTN...6 feet under from stroke, kidney failure and a billion other things critical htn will cause
also...if you take any ssri or serotonin modulating drug ie extacy....dont take this...there would be a great chance of life threatening serotonin syndrome'
i am just a little nervous about guys taking this...please give me some references telling me i am wrong....because this is what i found on my search" - decadon
...so I got pretty worried and stopped the Rho two days ago.However,now I'm thinking it's probably some inflamed trap/neck muscles that is giving me the headache(did some 750lbs. rack dead lockouts).Even if the headache is due to the training I'm not sure if it's safe to take w/ Effexor.
I really like Rho but I need to be sure it's safe.
Anyone else taking both Anti-D's and Rho?
Thanks for any advice.