This is BIG NEWS!
Just when everybody seemed to be taking for granted that DMAA was not naturally occurring, a new study publicated in the Analytical Chemistry Insights journal proves the FDA wrong against all expectations. The paper, titled Identification and Quantification of Dimethylamylamine in Geranium by Liquid Chromatography Tandem Mass Spectrometry, concludes that:
Regarding the isomers issue, which could also be used as an argument to consider the DMAA used in supplements (a racemic mixture) as not naturally occurring, this study proves that naturally occurring DMAA is a racemic mixture as well:DMAA, which is used in some nutritional supplements, has led some to question whether it is actually a constituent of the geranium plant and its oils. A validated method for quantification of DMAA in geranium plants has been established in the present investigation and has confirmed the presence of 1,3-DMAA (1) and 1,4-DMAA (2) in the plant tissue and essential oil. The conditions of LC and ESI positive MS/MS have been optimized. A simple and rapid procedure for sample extraction and purification has been developed. This LC/MS/MS method is sensitive and reliable and has been used successfully for the simple and rapid analysis of DMAA in the geranium plant and its oils.
http://www.la-press.com/identificati...-article-a3297The results from the present study show that 1,3-DMAA (1) has two isomer peaks which are present in equal amounts and which are identical in all tested samples, including the standard reference. The reference standard of 1,3-DMAA (1) is synthetic and produced via chemical reaction. However, most compounds present in plants should be made through an enzymatic process. Therefore, most likely only one chiral configuration would be present in plants (often referred to as natural form). The results in the current study show that 1,3-DMAA (1) in geranium plants and geranium oils appears to be an exception to this notion. Indeed, this is not the first report demonstrating the presence of a racemate in a plant tissue.
So, not only is DMAA naturally occurring, but also the racemic mixture of isomers found in both geranium plants and oil has an enantiomeric ratio very similar to that found in DMAA containing supplements. I wonder, after this, what new excuse will the FDA come with in order to keep pushing this nonsense ban?