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  1. #1
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    Default Checking out the Mind part

    I was led here by links about methylation and histamine intolerance. I've got plenty to read before I ask any questions.

    As you were.

    -Nicole

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    welcome


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    also interested in the mind enhancement aspect. Health and fitness too of course

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    Hi .

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    Histamine intollerence is probably a red-herring, by which it can in fact be the case that L-Histidine could reduce allergic type inflammation, based on case reports, rather than increase it. Unfortunately dietary loading with L-Histidine *normally* results not in Histamine production in the liver, but cholesterol and fatty acid synthesis, due to degradation, which is then shipped to the blood. If dietary Histadine is not being normally metabolised by the liver, it may have different effects. However, L-Histadine may normally be stored in Carnosine, by combination with Beta-Alanine. Again, broadly, Carnosine is anti-allergic/anti-inflammatory, but some people do respond allergically to it, at least transiently. I believe longer term use actually induces tollerence and antiallergic effects. A solution may be to increase Beta-alanine production or supply. Perhaps, L-Histadine conversion to Histamine is inappropriately elevated due to lack of endogenous supplies/synthesis of beta-alanine, in the liver or elsewhere.

    L-Histadine appears to have vital roles in blood cell generation, potentially of relevance to CFS. Hematopoiesis is apparently dependent on Histadine conversion to Histamine via Histadine decarboxylase. Now, Histadine to Histamine production is vital for many functions including sleep wake cycle and normal immune function. L-Histadine supplementation seems to have paradoxical anti-allergy effects, at least in some.

    Some things for you to think about, but the liver is probably the key place to start looking, as here also methylation is of great relevance. The liver converts many aminoacids and inflammation or liver injury/infection can result in major alterations in the synthesis and transport of various aminoacids, including beta-alanine IIRC and certainly, synthesis of L-Serine from Glycine. The possible interactions of beta-alanine and dietary histadine in the liver may play a role in the abnormal response presumed to happen with L-histidine, presumably also, when you have an excess number of inflammatory immune cells that use L-histadine to synthesise Histamine, but it may not be that clear or straightforward.

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