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  1. #1
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    Default GHRH Local Effect?

    Can GHRH have a local effect? Are there GHRH receptors in muscle or bone cells? GHenerate is a cheap and available GHRH. A transdermal application can be applied by applying DMSO and strong capsaicin, followed by GHenerate to the local area.
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  2. #2
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    Default Seems so

    Acceleration of wound healing by growth hormone-releasing hormone and its agonists. www.ncbi.nlm.nih.gov/pubmed/20937882
    Despite the well-documented action of growth hormone-releasing hormone (GHRH) on the stimulation of production and release of growth hormone (GH), the effects of GHRH in peripheral tissues are incompletely explored. In this study, we show that GHRH plays a role in wound healing and tissue repair by acting primarily on wound-associated fibroblasts. Mouse embryonic fibroblasts (MEFs) in culture and wound-associated fibroblasts in mice expressed a splice variant of the receptors for GHRH (SV1). Exposure of MEFs to 100 nM and 500 nM GHRH or the GHRH agonist JI-38 stimulated the expression of α-smooth muscle actin (αSMA) based on immunoblot analyses as well as the expression of an αSMA-β-galactosidase reporter transgene in primary cultures of fibroblasts isolated from transgenic mice. Consistent with this induction of αSMA expression, results of transwell-based migration assays and in vitro wound healing (scratch) assays showed that both GHRH and GHRH agonist JI-38 stimulated the migration of MEFs in vitro. In vivo, local application of GHRH or JI-38 accelerated healing in skin wounds of mice. Histological evaluation of skin biopsies showed that wounds treated with GHRH and JI-38 were both characterized by increased abundance of fibroblasts during the early stages of wound healing and accelerated reformation of the covering epithelium at later stages. These results identify another function of GHRH in promoting skin tissue wound healing and repair. Our findings suggest that GHRH may have clinical utility for augmenting healing of skin wounds resulting from trauma, surgery, or disease.
    Huh. Acts on wound-associated fibroblasts. So good for the old connective tissue, so long as it has such "wound-associated" fibroblasts. Perhaps joints (though I dunno what "wound associated" means for a fibroblast. I've been doing the aforementioned treatment on my knee. I do notice the same systemic effects including deep sleep and better recovery. Not sure if it has a stronger local effect or what. My experiment on myself is, of course, neither double blind nor unbiased. BTW:
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    U might think blood red is cool and all but can't fukin read that shit. thx.
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