How do YOU take NAC? What effect has it had on your mood, dopamine function, etc.???
And I have some questions...I've been taking NAC for two years now, at fairly nigh doses. I've taken anywhere from 1000-3600mg/day, and that includes taking Cerefolin NAC which is 600mg NAC along with b12 and methylfolate. I'm trying to understand whether I really need all this NAC at this point, and if it might be actually causing some negative effects at this dose.
I originally used these doses after reading the Berk studies from Australia, showing that 2400mg of NAC was effective for bipolar depression, which is my primary condition. But can someone help me out and explain to me what NAC actually does? My understanding is that it supports glutamate/cysteine exchange, which somehow both enhances glutamate activity in certain circuits, but also attenuates glutamate hyperactivity/toxicity? Is that true? Is it this effect or the glutathiaone effect that dominates in bipolar depression.
Also: why isn't it used for regular depression? I read through another thread here where Ex Dubio mentioned that it actually can HAMPER reward activity...given that I still struggle with anhedonia and motivation, is NAC actually harming me here? My mood has been overall pretty good the last three months due to intense exercise and DHEA and other stuff. I am also on heavy amounts of dopaminergics, including 600mg of bupropion, 0.5mg pramipexole, and 60mg vyvanse. How does the NAC fit into this? I am also taking Campral to help with "craving"...i am in AA for "addiction"-esque behaviors with respect to supplements and fucking with my meds. How would the high dose of NAC i'm on fit into THAT? I hear NAC is GOOD for OCD, right? But OCD is often a result of glutamate hyperactivity, so...? Anyway I'm confused, as you can see.
What would you predict would be the effect if I went down from my 2400mg of NAC to 600mg. Would positive affect improve? Impulsivity, reward-related, motivation, dopamine function...etc.
Really would value anyone's insights and please share your story of how YOU take NAC.