Mirtazapine has always struck me as one of the more novel psychoactive drugs. For old, underweight, depressed and tired people it is a godsend often.
However in all the studies on Pubmed etc, the weight gain is a common adverse effect. Some people say that it gave them intolerable carb cravings and they put on 10kgs+.
When I tried it I found I immediately put on about 5kgs. My friend told me I looked like a white George Foreman (before his low fat grill) so I decided I had better get back into shape and ease up on the treats. I then lost about 3kgs.
I am curious about the link between the weight gain and Mirtazapine's effects on Ghrelin & Leptin.
Leading on from this, I am also curious about the various ways, via supplementation or additional medications, that this weight gain can be attenuated. I like the way I sleep when I am on Mirtazapine but not keen on the unwanted gut
Appreciating anyone's thoughts