OK, now using the term "confirmed" loosely here Gentlemen, but here is the story:
A while ago I had used 2-3 mgs of Melatonin per night to treat my lifelong insomnia with great initial success. However, after about 2 weeks, I started feeling immensely depressed. I started a thread on this but that thread seems to have vanished. In fact, i was able to locate another post of mine where I am linking to that thread about melatonin, yet the link has turned dead. Check it out:
(click on the link in this post and see what happens... Mods, any way I can access that thread? I am pretty sure it wasn't locked by Mods)
Anyways, 10 days ago I started Melatonin again to give it one more shot. This time, my goal was to use it every other day or maybe 4 nights a week max. I was under the very analytically-confirmed and ultra-intelligent impression that the depression during the prior episode was the result of not melatonin itself but excess sleep, one of the logical paths leading to this conclusion being that sleep deprivation can be a short term treatment for severe depression. Hence, I thought, the reverse may be true and sleeping too much can cause depression. Ex Dubsy slapped me on the head and said that such is not really possible but I knew the depressive thoughts came out of nowhere and had nothing else to attribute them to other than melatonin or longer/ deeper sleep hours.
Long story short, I have used melatonin for the last 10-11 days every other night and for the last 2-3 days I am depressed as hell. This is VEEEEERY unusual for me. I have not had depressive episodes in hyears and certainly never experienced depressive thoughts out of the blue like this at any point in my life.
The thoughts and emotions that I have can be best summed up by the word pessimism. I developed such a bleak outlook and such negative future projections, which is exactly what I had experienced last time melatonin.
I have done a pubmed search with the words depression and melatonin and only get abstracts where melatonin is used to treat depression. They are having a moderate amount of success with it, but that is to be expected. If an individual who is severely depressed and hasn't had a good night's sleep in months if not years is sleeping well for the first time with melatonin, of course they are going to feel better (am I doing something wrong here? any ideas for ways/keywords to use in order to uncover studies where the effects of melatonin was observed on un-depressed people?)
However, a google search does bring up some anecdotal reports of "since I began using melatonin, I am feeling depressed". Also check this out:
University of Maryland Medical Center
"Some studies show that melatonin supplements worsened symptoms of depression." though which of the studies they cite at the bottom of the page -if this study is even included- says so is unclear.
Now, one more time, am I seeing ghosts where there are none or is there a possible MOA whereby melatonin can cause depression?
The reason I pursue melatonin is that it really does make a huge difference and seems to work in a different way than all other sleep meds I tried (and I tried a lot). Two critical differences:
1- It produces a very alert state the next day. With all other medicines, some part of the psyche is still asleep the day after, even if you have tons of physical energy. With melatonin -and this doesn't happen every time I use melatonin but happens often- the next day I am fully awake. Every dimension of the soul is there, ready for action and fully present as opposed to dormant. I know, this is somewhat of an esoteric description, but I am sure the intelligent members of this forum got the point.
2- The effects go beyond the immediate future while melatonin is still in the blood. Melatonin seems to reset something. After I quit using it the last time, I felt different and better for a month if not longer. I was falling asleep more easily and the next day I was more fully awake. This carryover effect dissipated with time. This time too, I feel the same may (only may) happen if I can continue to use melatonin for a while as I am feeling a change that is likely deeper and more profound than I have achieved with any other sleep medicine.
(disclaimer here: Lunesta + 100 mg pregabalin have a similar effect and they even more dramatically reduce the need for sleep, yet I have never tried that combo two noghts in a row, let alone twice over the course of one week, and do not intend to)
My question here is: could melatonin "reset" something and have lasting effects based on what we know of it?
Finally, could it be helpful to try either ramelteon or agomelatine? They bind to melatonin receptor subtypes, so maybe they could still result in similar benefits in terms of sleep but due to specific as opposed to general melatonin receptor affinity, the side effetct of melatonin can be avoided. Am I kind of right or totally off base here? Other similar drugs worth looking into?
Thanks in advance everyone....