Yet in the long run, too much dopamine can cause dopamine dysregulation and distressing mood swings—both highs and lows. Excess dopamine can lead to chronic low dopamine. The brain's reward circuitry is finely tuned and quite plastic. Addiction research reveals that if we flood it with dopamine (as cocaine users do), it begins to recalibrate itself to cope with excess.
Just as you might close windows when a thunderstorm rolls in, your reward circuitry down-regulates the receptors for dopamine on key nerve cells after over-stimulation. Especially with repeated episodes, the reward circuitry assumes that another "storm" is on the way, so it may not return to its usual configuration right away. It becomes desensitized. (Parkinson's drugs also tend to lose their effectiveness over time.)
The result of down-regulation? Normal levels of dopamine won't trigger those subtle feelings of optimism and anticipation that make arising in the morning an attractive proposition. Such sluggishness is a hangover, but it's also withdrawal. It's normal to feel rotten while our brain recalibrates so it can, once again, respond normally to dopamine.
Meanwhile, we can become so desperate to "feel right," that we may reach for any of the many stimulating activities and substances that goose dopamine: drugs, alcohol, impulsive spending, junk food, Internet porn, gambling, engaging in "forbidden" sex, and so forth. Alas, more stimulation can cause further down-regulation—and an even stronger urge for relief. In short, dopamine lows, just like dopamine highs, can drive compulsive behaviors.
This may be why "Depression is strongly linked to high-risk behavior, including drug use, alcoholism, and risky sex." Some assume that depression leads to acting out, but it's possible that over-stimulation leads to depression (chronic low dopamine), followed by risky attempts to self-medicate by seeking dopamine surges.
Apart from that risk, fostering addiction in orgasm lovers could provide a secondary bonanza for drug companies. They are already testing "anti-addiction" pharmaceuticals that manipulate the reward circuitry of the brain by...you guessed it...blocking the effects of dopamine. Trials have caused some patients severe depression and even resulted in suicide. And what do you take if you're not orgasming as easily as you like, but also have an addiction??
This an extract of Dr Wilson about dysregulation of DA.
My first question how to optimize DA, especialy to up regulate D2 recptors ?
My second question, do low dose of APM down regulate DA 2 receptors and with time make you more vulnerable to dopamine dysregulation ?