I know opioids work by agonizing mu-opioid receptors, but why does that cause such an effect? It feels remarkably different from every other drug I have experienced. How could activating a receptor cause perfect contentment, instant alleviating of depression, anxiety, emotional and physical pain?
I guess what I mean is, we all say this drug works by activating this receptor. Well, duh, but what happens next? I guess I need some kind of primer on neuroscience. Any suggestions?