I'm becoming interested in AChE inhibitors. They seem to be helpful in lyme-related long-term memory loss (I can barely remember anything about my adolesence and early 20's, its pretty sad). They seem to increase libido:
<div class='quotetop'>QUOTE (rxlist.com)</div><div class='quotemain'>Adverse Effects Reported In Clinical Trials [for Donepezil]
Nervous System: Frequent: delusions, tremor, irritability, paresthesia, aggression, vertigo, ataxia, increased libido</div>
<div class='quotetop'>QUOTE (Brooklyn Tony)</div><div class='quotemain'>I bought some huperzine A today with 60 mg of ginko extract. I have used this a long time ago but forgot what effects it had upon me. My interest in using this again as a supplement stemmed from an article I read about this being a NDMA receptor antagonist.
I took 100 mcg of the stuff (2 caps) and I feel the following:
Very mentally sharp, effect took 20 mins
Talkitive, I cant shut up! this is a good sup for socializing
Not particulary anxious at all, even though I get bad anxiety with ginko sometimes (gingko doesnt do much for me)
And I dont want to say it lifted the depression I got from the phenibut withdrawals but I feel pretty good.
does anyone think because of these effects you can use huperzine off label as an antidepressant? ive been feeling pretty good the past few days, and my libido is higher than its been in a while</div>
Huperzine and donepezil increase DA release in various ares of the brain (PMID: 16923332) and possibly NE as well (PMID: 7500384).
Huperzine is also an NMDA antagonist and might help your brain survive DAA experimentation (PMID: 18588864 and PMID: 11825682). Even US Army researchers like it for this purpose (PMID: 11920920). Not just NMDA though, huperzine is broadly neuroprotective against a wide variety of insults (PMID: 15956816).
Both huperzine (PMID: 10678121) and donepezil (PMID: 12105320) enhance memory and learning in healthy individuals, demonstrating a genuine nootropic effect.
A couple people that liked donepezil, one you know, one you don't:
<div class='quotetop'>QUOTE (Dopamine)</div><div class='quotemain'>Got the Donepezil yesterday afternoon. Took 5 mg. Early observations:
- Increased self confidence
- Slight dizziness
- Senses much more "sensitive", i.e. noticing more details in physical objects
- Increased irritability, more argumentative and hostile
Donepezil seems also to potentiate my response to methylphenidate, another interesting observation.
This is definetly something I would consider taking daily, as it feels like it is stimulating "central" structural regions of my brain.
It's been almost a week now since I've consistently taken Donepezil at 5 mg in the morning. Something else I've noticed is that my sleep quality has greatly improved, and that I generally require about 1-2 hours less sleep per night.</div>
<div class='quotetop'>QUOTE (utopizen @ dr-bob)</div><div class='quotemain'>One year on Aricept- ADD augmenter, sleep booster
Posted by utopizen on May 25, 2006, at 16:21:57
Yeah, just wanted to report my year now with a low dose (5mg) of Aricept.
For one thing, why did I start it?
I had social anxiety disorder really bad, along with ADD-inattentive subtype.
I began reading journal articles in 2002 with doctors finding unique findings in patients with the combination of social anxiety disorder and ADD.
Around the same time, the big Asperger's Syndrome push came around, trying to explain that you don't need to see Rain Man before diagnosing someone with Asperger's.
Anyhow, I am on the following regimen:
Klonopin Wafers (now generic!) 1mg 3x/day
Desoxyn 5mg 2x/day
Evoxac 30mg 3x/day (for dry mouth)
Nexium 1x/day for GI side-effects of Aricept
Well, I did attempt after a few months to go up to the regular dosing of 10mg (5mg is starting dose for geriatric patients).
Long story short, I went manic for a few hours, it wasn't pleasant, but taking a Klonopin like with anything subdued the matter immediately.
So I returned and stayed at 5mg.
I was able to lower my dose to 5mg of Desoxyn 2x/day, while the average daily dose is 20-25mg/day.
One thing I noticed when it began kicking in after a couple of months of being on it (2-3 months) was this incredibly refreshing sleep. The moment I awoke, whether it was a nap or during normal bedtime, I would find myself very restored.
I also needed just 7 hours of sleep, and nothing more, to go all day long.
I also had this sort of "automatic thinking" - I noticed it first when I awoke from a nap to a call, answered it, and the person on the other line said, "oh, I didn't mean to wake you" and I said "oh, no problem" all of a sudden energetically, and then he said something for a bit, and I spun off clearly and articulately (yet faster than I've ever talked) a few smoothly constructed sentences as though someone else had just written my response and orated it on my behalf.
Well, I also managed to give presentations like this too-- concise, to-the-point, measured, quick-witted, and very cohesive. I just sort of would come in and out of topics with such ease.
I even could exit gracefully (for the first time in my life) -- I would end the conversation I had to end by saying something very relevant to what had just been said by another person, and quickly cap it off with a "well, I have to go, but good to meet you, and we'll talk later" (an example) with no hesitation and total ease.
Sounds oddly simple, but you have to understand the subtle nature of how smooth and effortless things like this became to me that were once incredibly difficult or frustrating.
I felt like that kid in the movie Thumbsucker (2005) -- and I have tried every ADD stimulant, and nothing came close to what happened when I combined Aricept with a stimulant.
Anyhow, hope everyone is well.
By the way, my mood, and energy, and everything, has been rock solidly awesome for a year now.
My doc over last summer, after a couple of months into regimen, said "This is the best I've ever seen you!"
(I came to him a year earlier, despondent and so depressed I couldn't hide it at all to anyone).
Huperzine seems like almost a donepezil/memantine hybrid due to its unique pharmacology, except maybe better than memantine for cognition because it enhances rather than trashes cholinergic neurotransmission.
Which drug is better, for specific indications and/or in general? Any updated experiences with either drug?