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Thread: Noopept

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    How many of you guys have heard of Noopept?

    This is a more powerful racetam/dipeptide that was developed over in Russia and is currently being sold over there as viagra for the human mind. It's marketed as a memory enhancer.




    Here's an interesting report I read from someone whose tried this on another forum:

    <div class='quotetop'>QUOTE </div><div class='quotemain'>Originally Posted by Riemann Zeta
    Noopept (GVS-111) - First Trial - This One's Special

    This is my first trial of an experimental pre-clinical cognitive enhancing compound known as Noopept (GVS-111). The compound could loosely be called a piracetam derivative, but in reality it is a pyrrolidine-containing dipeptide. The standardized long-form chemical name of noopept is: N-phenylacetyl-L-prolyl-glycine ethyl ester...just rolls off the tongue, right? Despite the fact that it is a peptide, it is said to be bioavailable and gets to the brain after sublingual, oral and (probably) intranasal administration. Anyway, like the more well known phenylpiracetam, this compound is a Russian-designed nootropic indicated as a neuroprotectant and general cognition expander. There is an older Russian paper (Ostrovskaya et al, 2002) claiming that it is 200-50000 times as potent as good old piracetam in animal models of drain bamage . As it turns out, it's good shit. While phenylpiracetam didn't live up to its promised (i.e. extraordinarily hyped) potency compared to the rest of the 'racetam series, but this one might.

    My first dose was a modest 5mg, taken sublingually. Not too much was noticed, effect-wise. Anything that was noticed was likely placebo, a result of the overall excitement of trying a brand new experimental chemical. The second dose the next day was 10mg, again taken sublingually. This time the effects were more apparent: a general increase in alertness/awareness without any kind of amphetaminergic stimulation. Over the next few days, the dose was increased to 10-15mg BID. The effects of this compound seem cumulative, increasing over a few days of dosing (like most of the other piracetam derivatives). During the 4th or 5th day in, I definitely notice an increase in fluidity while writing--it seems more effortless--and my attention is increased. I normally take dextroamphetamine daily for ADD and noopept syncs very nicely with the amphetamine. Pramiracetam was another racetam compound that I found to sync well with amphetamine, but it seemed to greatly increased jaw muscle tension (which I normally don't get unless I'm on a psychedelic). Noopept, on the other hand, feels extremely smooth and crystal clean in concert with (d)-amphetamine. In addition, noopept seems to exert a nice light anxiolytic effect--not a sedating anxiolytic effect, but a feeling that you can handle multitasking without getting overwhelmed.

    In short, noopept is highly recommended--it is probably the best piractam-like compound that I have tried (a list that includes piracetam, aniracetam, oxiracetam, pramiracetam and phenylpiracetam). If I had to stand up and pull a number out of my ass, I would say that it is at least a 1000 times the potency of piracetam, but with more enjoyable and profound effects.</div>



    Unfortunately, The only way to get Noopept at the moment here in the States is thru another chemical supply company (who probably sell miniscule amounts for high $) or Bulk order. Here's an e-mail, I've recieved from a supplier for the bulk order of Noopept:

    <div class='quotetop'>QUOTE </div><div class='quotemain'>thank you for your inquired
    For the GVS-111 the price for 225 gram is USD 1500 , 450 grams is USD 2000, 1kg is USD 3000
    deliver time is 4 weeks, and you need prepay .
    If you have any comment, pls let me know, I will try to help you</div>

    From various studies, it seems no more than 50 mg (a quite excessive amount) of Noopept would be used per day. $1500/6=$250 per person (still alot of $ unfortunately), which would mean 225grams/6=37.5grams (37,500mg) per person for $250. 37,500 (total mg)/50 (mg per day)=750 days if someone were to take all the way up to 50 mg per day (which may not be recommended).

    At 365 days in a year, this amount could last someone about 2 years (and that's only if they took it in higher amounts every day, which I beleive is an overly excessive amount and wouldn't do) based on the math for a bulk order of 6 people ordering 225 grams and splitting it up amongst themselves.

    I'm not trying to suggest that I'm personally going to bulk order anything but just thought this would be an interesting peice of info. for you guys to look at. Feel free to respond with insight of your own.

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    Senior Member enemy's Avatar
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    I'll try anything once.




    Well except buttsecks.
























    No I'd try that, too.

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    Senior Member The Bionic Man's Avatar
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    Very interesting. Doing some research on it now. I think a health stor in a Russian neighborhood might be worth a try. Maybe I'll head to Brighton Beach today!

    One of the RC suppliers I've mentioned here (not your typical bb RC stuff) has it on their list for $95 for 500 mgs.
    PM me if interested.

    Interesting:

    <div class='quotetop'>QUOTE </div><div class='quotemain'>I am surprised that more people are not trying this and reporting. It has very favorable studies on pubmed.
    1.5 years ago I bought noopept from TLR and then imported it from Russia through someone I contacted on the internet (I offered him double the cost so $20/500mg and bought 5 boxes, also exporting medicine in Russia is illegal)
    From the literature I decided the optimal dosage was 50mg/day, importing from Russia was a hassle, and I ran out of money.
    It did not give me some crazy photographic memory effect I was looking for at the time when I was also taking 10 other nootropics, so I decided it was not worth it to continue at the moment.
    I got a synthesis quote from China, $1700/1kg, I intend to get it synthesized when I get a full time job.
    Also I recently came across this: http://www.bluelight.ru/vb/showthread.php?t=417159
    Maybe Sublingual is more effective?</div>

    Appaently there's plenty on pubmed too. If the price was right (i.e. cheap), it would be worth trying...

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    This is my reply from the similar thread at ImmInst -

    <div class='quotetop'>QUOTE </div><div class='quotemain'>I have tried it and didn't notice any effects from doses ranging from under 1mg up to 100mg. I seem to be a non-responder to most nootropics, so your results could very likely be different. I'm also the person that started that thread at bluelight and reposted Riemann Zeta's trip report. I ordered mine from TLR, their customer service is excellent. I have the synthesis procedure for noopept and it doesn't look too hard or require special equipment, if anybody is interested. I've got like 250mg left in solution, so I'm looking for people I know locally that would like to try a dose. There's more info in this thread where I speculate that noopept is probably a pro-drug of something else - http://www.imminst.org/forum/index.php?showtopic=27545.</div>

    About me looking for people locally to try it, I'm near M&M HQ so if any of you guys are interested I'd be glad to hook it up. The only reason I don't want to ship sample doses is that it's in an alcohol solution and would probably need special shipping.

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    <div class='quotetop'>QUOTE </div><div class='quotemain'>Very interesting. Doing some research on it now. I think a health stor in a Russian neighborhood might be worth a try. Maybe I'll head to Brighton Beack today!</div>

    I've thought about using this sort of strategy but haven't really followed thru on it. Russia is very stringent with the pharmacy's in their country and don't allow online internet suppliers to ship internationally at all. Therefore, I'm guessing that most of the US based pharmacy's that cater to the Russian crowd may not not be able to order Noopept. I've tried 1 Russian pharmacy (apteka) asking about special arrangements and all I heard back was "NO". When I asked why, I got no response.

    On the Imminst site, there's a thread that lists a number of different Russian based nootropic messageboards. The best advice I can give is to start up an e-mail on "yandex" (the google equivalent over in Russia) to recieve Russian e-mails then join one of the sites and make a deal with someone over in Russia to personally send it by Economy mail labelled a "gift".

    Otherwise, there's always the bulk order route.

    The RC supplier I'm familiar with. I like their price, they just need to increase their quantity and I'd be good.



    <div class='quotetop'>QUOTE (skinniest200 @ Apr 15 2009, 06:44 AM) <{POST_SNAPBACK}></div><div class='quotemain'>This is my reply from the similar thread at ImmInst -



    About me looking for people locally to try it, I'm near M&M HQ so if any of you guys are interested I'd be glad to hook it up. The only reason I don't want to ship sample doses is that it's in an alcohol solution and would probably need special shipping.</div>

    If I was in the area, I'd give a shout out. I'd be interested in learning how to put this in liquid dosage form. I'm wondering how you determine the solubility of the compound and avoid possibly damaging it by keeping it in an alcohol based solution over time? This would be very interesting to find out.

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    <div class='quotetop'>QUOTE (yowza @ Apr 17 2009, 02:01 AM) <{POST_SNAPBACK}></div><div class='quotemain'>I'd be interested in learning how to put this in liquid dosage form. I'm wondering how you determine the solubility of the compound and avoid possibly damaging it by keeping it in an alcohol based solution over time? This would be very interesting to find out.</div>

    I just mixed it into a solution that made it 1mg/ml, with the liquid being half water and half 70proof vodka, so final alcohol content was about 17.5%. Solubility is definitely an issue - it's not very soluble in ice cold vodka, the liquid needed to be room temp to get decent solubility, and even then it's not perfect. The compound could possibly have been damaged from the vodka or tap water, but I thought it was supposed to be decently stable stuff. I just used the alcohol to keep the solution sterile, but I probably didn't need to use as much as I did.

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    <div class='quotetop'>QUOTE (The Bionic Man @ Apr 15 2009, 06:36 AM) <{POST_SNAPBACK}></div><div class='quotemain'>Very interesting. Doing some research on it now. I think a health stor in a Russian neighborhood might be worth a try. Maybe I'll head to Brighton Beack today!

    One of the RC suppliers I've mentioned here (not your typical bb RC stuff) has it on their list for $95 for 500 mgs.
    PM me if interested.

    Interesting:



    Appaently there's plenty on pubmed too. If the price was right (i.e. cheap), it would be worth trying...</div>


    I live not far from brighton beach if you find it there let me know!!!

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    All right. It looks like I didn't have to go thru a whole lot of hassle. I just ordered 4 boxes.

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    Much cheaper source now available, 10mg x 50 for $16 + shipping on brand name Noopept.

    Will post source if interest and mod approval, or just find it on ImmInst.

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    Senior Member Reddisert's Avatar
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    I would love to hear what people's feedback on this is like.
    A short Haiku about myself:
    <blockquote>How handsome I am
    It is obvious to see
    I have much free time </blockquote>
    How are you limiting yourself?

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    Bumping a very old thread. Anyone ever try this?



    I took some piracetam today and it appears I'm one of the few people that are sensitive to this drug. I'm feeling better than normal today. I figured that since I'm on a good dose of Depakote I might as well start taking the piracetam I've had sitting around for a while and finish the two boxes of it. We will see how it goes.

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    Quote Originally Posted by morganator View Post
    I figured that since I'm on a good dose of Depakote I might as well start taking the piracetam I've had sitting around for a while and finish the two boxes of it.


    Would you mind expanding on this? I have no clue why being on depakote gives you incentive to take piracetam.

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    Quote Originally Posted by Odium View Post
    Would you mind expanding on this? I have no clue why being on depakote gives you incentive to take piracetam.


    Yeah I didn't make that clear. For one, depakote may be causing some issues with cognition and clarity. Also, being on depakote should subdue the manic like effect piracetam had on me in the past. Anyway, my plan is to just take it for 6 months, if these next few weeks go smoothly, and hope that it has some lasting effects.

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    Dude, I had the remainder of a tub of 1fast400 piracetam laying around. So I took 3g.



    Lets just say given ample sleep time, its a far different experience than when I was sleep-deprived.



    If Noopept is piracetam x 1000, I want to try it badly.



    I would lean toward the effect being less "manic" than morganator described and more "hyperthymic" i.e. its a good feeling, not excessive or out of control.

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    To follow up on the previous post:



    I've been using 3g piracetam first thing in the morning for one week. I had last used it 5 years ago, and in that trial I had been chronically sleep deprived.



    I had been taking 3g late in the evening as well, but couldn't sleep so I discontinued the evening top up.



    Effects I've noticed:

    Even without the evening redose, I need less sleep than before.

    Creativity and motivation boost

    A (possibly resultant) confidence boost

    Heightened loquacity

    My memory is normally great, but for the moment I have preternatural recall.



    I'm on a low calorie cutting leangains type diet. When I am ketotic, my hands and feet get very cold, very easily and stay that way. Piracetam has done away with cold extremities of dieting all together. Its just gone. And I love it. And it also might have some anorectic effects or that might just be willpower becoming easier to enforce as a result of the diminished negative symptoms.



    A final point: I am a researcher. This compound is a perfect complement to my profession. If you're working on an assembly-line somewhere, I could see how piracetam would be fairly useless but for me, its exceedingly useful.

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    Incidentally, its no good for teaching effectiveness (pedagogy):



    I have a tendency to skip down the chain of reasoning in lecture, over connections that I feel are obvious but may not be quite so obvious to an uncertain pupil.

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    morganator, do you take omega-3s?

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    Tried it, Noopept is primarily a dud.. an unnecessary extra expense. No further comment.
    0 0
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    U

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    Quote Originally Posted by enemy View Post
    morganator, do you take omega-3s?


    Yes I do, have been for the last eleven years. The effects aren't as noticeable as they used to be. I imagine it is possible I might notice the same effects once I get my brain back to functioning more like it used to-omega 3s by themselves are not enough to do this.

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    There was a thread on imminst about omega-3 and piracetam potentiating one another, it seems to work for me

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