pyritinol

**eclypz** · April 29th, 2005, 02:47 PM

I was searching for more info on pyritinol and came across this study. Has anyone been keeping up on this sort of info????

cholestatic hepatitis in SHORT TERM treatment with PYRITINOL

They mention that it may be caused by something else but they certainly don't assert that.

**eclypz** · April 30th, 2005, 03:40 PM

Yeah if it was a study that consisted of several grams given to dogs for three months I would have ignored it myself. The study seemed to be careful to say there is an offchance it was something else, and maybe I'm reading it wrong, but it seems there is definitely a concern for not overdoing this product, using for brief periods or abstaining all together.

Anyone else have anything to add? Where's ergoman? Probably sleeping off his dogwood I imagine...

**ScottL** · April 30th, 2005, 04:22 PM

Eclypz,

This addresses your question:

http://www.imminst.org/forum/index.php?s=&...645&#entry32163

**virtualcyber** · April 30th, 2005, 07:15 PM

Just cutting and pasting ...

(1) Acute pancreatitis due to pyritinol: an immune-mediated phenomenon.

Straumann A, Bauer M, Pichler WJ, Pirovino M.

PMID: 9679051 [PubMed - indexed for MEDLINE]

(2) Occupational contact dermatitis due to pyritinol.

Contact Dermatitis. 1997 Aug;37(2):91-2. No abstract available.

PMID: 9285173 [PubMed - indexed for MEDLINE]

(3) Severe cholestatic hepatitis induced by pyritinol.

BMJ. 2004 Mar 6;328(7439):572-4. No abstract available.

PMID: 15001508 [PubMed - indexed for MEDLINE]

(4) Agranulocytosis associated with pyrithioxine therapy.

Am J Hematol. 1992 Dec;41(4):306. No abstract available.

PMID: 1288303 [PubMed - indexed for MEDLINE]

**Agranulocytosis is a condition in which there is an insufficient number of

white blood cells called neutrophils or granulocytes

(5) Drug-induced pemphigus diseases]

Dermatol Monatsschr. 1989;175(1):1-7. Review. German.

PMID: 2522066 [PubMed - indexed for MEDLINE

**skin erosion

(6) [Autoimmune hypoglycemia: the fault of pyritinol?]

Presse Med. 1988 Oct 8;17(34):1733-6. French.

PMID: 2978305 [PubMed - indexed for MEDLINE]

(7) [Auto-immune hypoglycemic syndrome induced by pyritinol]

Diabete Metab. 1988 Jul-Aug;14(4):423-9. French.

PMID: 3066650 [PubMed - indexed for MEDLINE]

(8) [Captopril induced lichenoid eruption]

Ann Dermatol Venereol. 1983;110(5):433-8. French.

PMID: 6354041 [PubMed - indexed for MEDLINE]

(9) Nephrotic syndrome during a treatment of rheumatoid polyarthritis with pyritinol]

Therapie. 1982 Jul-Aug;37(4):492-3. French. No abstract available.

PMID: 7135333 [PubMed - indexed for MEDLINE]

(1) Photosensitive dermatitis due to pyritinol.

Arch Dermatol. 1973 Mar;107(3):427-8. No abstract available.

PMID: 4266310 [PubMed - indexed for MEDLINE

**eclypz** · May 2nd, 2005, 03:31 PM

[quote name='ScottL' date='Apr 30 2005, 08:22 AM']Eclypz,

This addresses your question:

http://www.imminst.org/forum/index.php?s=&...645&#entry32163

[snapback]238510[/snapback]

[/quote]

Does it? I don't mean to be flippant, but does he address this specific study and state why he thinks it's not a problem? Was it the comment he made regarding the hypothesis that this sort of issue is only a problem with rheumatoid arthritis patients? Other than that I simply see him say that it's been used for years and is regarded as safe.

**ScottL** · May 9th, 2005, 01:07 AM

eclypz ,

Before you give up on pyritinol you might want to ask Lifemirage for clarification yourself. He is a clinician (psychiatrist I think) who uses nootropics in his practice, and is writing a book on nootropics.

He posts and answers questions on the imminst board.

**FunkMasterFlex** · May 9th, 2005, 01:56 AM

yeah he is quite the brain over there. He has helped to steer me (just by reading his posts) in many of the right directions

**ScottL** · May 9th, 2005, 04:20 AM

Just ran across this from 5/3/05 imminst board re: pyritinol:

http://www.imminst.org/forum/index.php?s=&...235&#entry59311

Originally Posted by LifeMirage

It is a safe compound.

It has been studied in healthy people with no side effects.

Your fears are based on a handful of people over probably 500,000 or more people who have used it with no problems?

Yet you consume foods, breathe air, and drink water full of toxic compounds everyday without that fear?

Seriously your fear is not based on the weight if scientific evidence.

And as far as your reasoning Pyritinol is effective in treatment RA and improving the quality of life in the patients. There is no study showing Pyritinol to be toxic, causing serious or lasting damage to the body.

**eclypz** · May 9th, 2005, 10:15 PM

I appreciate his response, Scott. I also appreciate the fact that pyritinol has been used for a long time with little in the way of any major problems. I don't however think it's totally unfounded to have a concern regarding the potential problem this may have.

If I decided to invest some time into this I will join imminst and discuss with him my concerns. Until then I'll just leave it be.

Thanks again

**ScottL** · May 24th, 2005, 10:29 AM

May as well cross post this last thread which addresses eclypz study above:

http://www.imminst.org/forum/index.php?s=&...494&#entry61844

from the above link:

"But just to note I have personally given Pyritinol to over 1,000 people without any problems"